Abstract—Ageing has been a mystery to humanity for
millennia. It has been a burden for numerous people, from the
minority that suffer from progeria to the plethora of people who,
due to ageing, are more susceptible to diseases such as
Alzheimer’s disease and coronary artery disease. The aim of
this study was to identify genes that regulate aging and
elucidate their mechanisms. A Caenorhabditis elegans RNAi
screen was performed to assess the role of these genes in the
regulation of aging. For the first time, D2030.4 deficiency was
found to accelerate senescence at 20 °C, comparable to DAF-16,
a putative regulator of senescence. The results showed that
D2030.4 deletion could down-regulate the expression level of
GAS-1 mRNA and actively participate in the regulation of ROS
in mitochondria. Therefore, D2030.4 may inhibit senescence by
regulating ROS production. The Caenorhabditis elegans gene
D2030.4 is conserved in many species, including humans,
making it a potential target for anti-aging drugs.
Index Terms—Ageing, mitochondrial respiratory chain,
caenorhabditis elegans
Qinya Liu is with King’s College Soto de Viñuelas in Madrid, Spain.
Yang Li is with Zhejiang University in Zhejiang, China.
*Correspondence: 11618021@zju.edu.cn (Y.L.)
[PDF]
Cite: Qinya Liu and Yang Li, "Research on Ageing Based on D2030.4 by RNA Interference Impairs Lifespan in Caenorhabditis Elegans," International Journal of Engineering and Technology vol. 15, no. 4, pp. 149-155, 2023.
